4-[N-Dodecyl-N-2-[4-[3-hydroxy-4,4,4-trifluorobutyl]phenoxy]ethylamino]butanoic acid, ethyl ester → (2S, 4S)-1-N-Dodecyl-4-[4-[3-hydroxy-4,4,4-trifluoro-1-butyl]phenoxy]pyrrolidine2-carboxylic acid, methyl ester

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Reaction Steps

(2S, 4S)-1-N-Dodecyl-4-[4-(E)-[3-hydroxy-4,4,4-trifluorobut-1-en-1-yl]phenoxy]pyrrolidine-2-carboxylic acid, methyl ester (552 mg., 1.07 mmol) was hydrogenated as described in the preparation of 4-[N-dodecyl-N-2-[4-[3-hydroxy-4,4,4-trifluorobutyl]phenoxy] ethylamino]-butanoic acid, ethyl ester and afforded the title compound (546 mg, 99%) as a clear oil. [a]D=−89.0° (c 0.4, CHCl3)

Provenance & Evidence