HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-[4-[2-(N-dodecyl-N-ethylamino]ethoxy]phenyl]-1,1,1-trifluoro-2-butanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-Ethyl-N-[2-[4-(3,3-dimethoxy-4,4,4-trifluoro-but-1-yl)phenoxy]ethyl]dodecylamine | HCID 18319013 | — |
| Reactant | 4-[N-dodecyl-N-[2-[4-(3oxo-4,4,4-trifluorobut-1-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester | HCID 86757122 | — |
| Product | 4-[4-[2-(N-dodecyl-N-ethylamino]ethoxy]phenyl]-1,1,1-trifluoro-2-butanone | HCID 18319016 | 54% |
Reaction Steps
N-Ethyl-N-[2-[4-(3,3-dimethoxy-4,4,4-trifluorobut-1-yl)phenoxy]ethyl]dodecylamine (123 mg, 0.244 mmol) was treated with trifluoroacetic acid as described in the preparation of 4-[N-dodecyl-N-[2-[4-(4,4,4-trifluoro-3-oxobut-1-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester and afforded the title compound (60 mg, 54%) as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06255496B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-85e529a433b94717a712afbdcee1e1e1 |
| Source note | uspto-grants-2001_07 |