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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1383985Generated: October 31, 2026

Trifluoroacetic acid → 2-(4-Chlorophenoxymethyl)-4-[3-(piperidin-3-yl)propoxy]-1-[3-(piperidin-3-yl)propyl]benzimidazole

https://huagongshe.com/reaction/1383985

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant2-(4-Chlorophenoxymethyl)-4-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propoxy]-1-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propyl]benzimidazoleHCID 21188772—
Product2-(4-Chlorophenoxymethyl)-4-[3-(piperidin-3-yl)propoxy]-1-[3-(piperidin-3-yl)propyl]benzimidazoleHCID 10605127—

Reaction Steps

The title compound is prepared from (R) 2-(4-chlorophenoxymethyl)-4-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propoxy]-1-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propyl]benzimidazole by standard deprotection techniques using trifluoroacetic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06255494B1
Source datasetuspto-grants-2001_07
ORD IDord-47df2519df984c9cbc1aa4a42cbb9f99
Source noteuspto-grants-2001_07