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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1383989Generated: October 31, 2026

Trifluoroacetic acid → 2-(4-Chlorophenoxymethyl)-4-[5-(piperidin-4-yl)pentoxy]-1-[5-(piperidin-4-yl]pentyl]benzimidazole

https://huagongshe.com/reaction/1383989

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant2-(4-Chlorophenoxymethyl)-4-[5-[1-(t-butoxycarbonyl)piperidin-4-yl]pentoxy]-1-[5-[1-(t-butoxycarbonyl)piperidin-4-yl]pentyl]benzimidazoleHCID 21188681—
Product2-(4-Chlorophenoxymethyl)-4-[5-(piperidin-4-yl)pentoxy]-1-[5-(piperidin-4-yl]pentyl]benzimidazoleHCID 70162346—

Reaction Steps

The title compound is prepared from 2-(4-chlorophenoxymethyl)-4-[5-[1-(t-butoxycarbonyl)piperidin-4-yl]pentoxy]-1-[5-[1-(t-butoxycarbonyl)piperidin-4-yl]pentyl]benzimidazole by standard deprotection techniques using trifluoroacetic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06255494B1
Source datasetuspto-grants-2001_07
ORD IDord-b391e466a4974cac99237fa18ccf59ac
Source noteuspto-grants-2001_07