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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1383995Generated: October 31, 2026

Trifluoroacetic acid → (RS) 2-(4-chlorophenoxymethyl)-4-[(piperidin-3-yl)methoxy]-1-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propyl]-benzimidazole

https://huagongshe.com/reaction/1383995

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant(RS) 2-(4-chlorophenoxymethyl)-4-[[1-(t-butoxycarbonyl)piperidin-3-yl]methoxy]-1-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propyl]-benzimidazoleHCID 21188665—
Product(RS) 2-(4-chlorophenoxymethyl)-4-[(piperidin-3-yl)methoxy]-1-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propyl]-benzimidazoleHCID 21188730—

Reaction Steps

The title product is prepared from (RS) 2-(4-chlorophenoxymethyl)-4-[[1-(t-butoxycarbonyl)piperidin-3-yl]methoxy]-1-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propyl]-benzimidazole using a standard trifluoroacetic acid deprotection protocol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06255494B1
Source datasetuspto-grants-2001_07
ORD IDord-8c82f4ec64d2477584afe79d85a20f62
Source noteuspto-grants-2001_07