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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1383998Generated: November 1, 2026

Trifluoroacetic acid → (RS) 2-(4-chlorophenoxymethyl)-4-[5-(piperidin-4-yl)pentoxy]-1-[3-(piperidin-3-yl)propyl]-benzimidazole

https://huagongshe.com/reaction/1383998

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant(RS) 2-(4-chlorophenoxymethyl)-4-[5-[1-(t-butoxycarbonyl)piperidin-4-yl]pentoxy]-1-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propyl]-benzimidazoleHCID 21188530—
Product(RS) 2-(4-chlorophenoxymethyl)-4-[5-(piperidin-4-yl)pentoxy]-1-[3-(piperidin-3-yl)propyl]-benzimidazoleHCID 21188664—

Reaction Steps

The title product is prepared from (RS) 2-(4-chlorophenoxymethyl)-4-[5-[1-(t-butoxycarbonyl)piperidin-4-yl]pentoxy]-1-[3-[1-(t-butoxycarbonyl)piperidin-3-yl]propyl]benzimidazole using a standard trifluoroacetic acid deprotection protocol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06255494B1
Source datasetuspto-grants-2001_07
ORD IDord-37fa97cb9ad248148656b1d6343c8c82
Source noteuspto-grants-2001_07