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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1384026Generated: November 2, 2026

Trifluoroacetic acid → (RS) 4-[3-[2-(pyrroldin-1-ylmethyl)pyrrolidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-(piperidin-4-yl)propyl]benzimidazole

https://huagongshe.com/reaction/1384026

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-[3-[2-(Pyrroldin-1-ylmethyl)pyrrolidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-[1-(t-butoxycarbonyl)piperidin-4-yl]propyl]benzimidazoleHCID 70163641—
Product(RS) 4-[3-[2-(pyrroldin-1-ylmethyl)pyrrolidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-(piperidin-4-yl)propyl]benzimidazoleHCID 20669079—

Reaction Steps

The title compound was prepared from (RS) 4-[3-[2-(pyrroldin-1-ylmethyl)pyrrolidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-[1-(t-butoxycarbonyl)piperidin-4-yl]propyl]benzimidazole using trifluoroacetic acid deprotection as described supra.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06255494B1
Source datasetuspto-grants-2001_07
ORD IDord-731e6350bce249faa6368ee7bff2ffe8
Source noteuspto-grants-2001_07