Azobisisobutyronitrile → HCID 86757133, compound

Participants

Reaction Steps

1 g (0.0017 mole) of t-butyl 3α-(5-norbornene-2-carbonyloxy)-7α, 12α-dihydroxy-5β-cholan-24-oate prepared in Example 4, 0.17 g (0.0017 mole) of purified maleic anhydride, and 0.0056 g (2 mole %) of 2,2′-azobisisobutyronitrile as a radical polymerization initiator, were dissolved in 3 ml of toluene solvent. The solution was introduced into a polymerization glass tube ampule which was then sealed under vacuum. Then, the solution was polymerized at a temperature of 65° C. for 20 hours. After the polymerization, the polymerization product was precipitated in petroleum ether/ethyl ether(5/1, volume ratio), and the precipitate was recovered with a glass filter. The recovered material was dried under vacuum at a temperature of 40° C. for 12 hours, thereby obtaining 0.37 g (32% yield) of poly(t-butyl 3α-(5-norbornene-2-carbonyloxy)-7α, 12α-dihydroxy-5β-cholan-24-oate-maleic anhydride), as a white solid.

Provenance & Evidence