Water → 2,5-Difluorophenol allyl ether

Participants

Reaction Conditions

Reaction Steps

2,5-Difluorophenol (10 g) was dissolved in dimethylformaldehyde (120 ml). At room temperature, potassium carbonate (21 g) and allyl bromide (8.57 ml) were successively added to the mixture and it was stirred at 80° C. for 1 hr. After adding water to the liquid reaction mixture, it was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (developing solvent: 5% ethyl acetate/n-hexane) to give 2,5-difluorophenol allyl ether (13 g) as a colorless oil.

Provenance & Evidence