HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 1-Phenyl-4-[(5-phenyl-3-pyridyl)methyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | 3-Methyl-5-phenylpyridine | HCID 598136 | — |
| Reactant | 3-(Chloromethyl)-5-phenylpyridine | HCID 11084925 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-Phenyl-4-[(5-phenyl-3-pyridyl)methyl]piperazine | HCID 11121047 | — |
Reaction Steps
2.04 g of 3-chloromethyl-5-phenylpyridine (“A”) [obtainable for example by radical chlorination of 3-methyl-5-phenylpyridine] and 1.62 g of 1-phenylpiperazine are dissolved in 200 ml of acetonitrile and the mixture is stirred for six hours at room temperature. After customary work-up, 1-phenyl-4-[(5-phenyl-3-pyridyl)methyl]piperazine, m.p. 83-85°, is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258813B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-015cfc50b8e94d0ebd10ef31c4dde1af |
| Source note | uspto-grants-2001_07 |