HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Benzyl 3-(3-pyrrolecarboxamido)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Diethyl cyanophosphonate | HCID 76257 | — |
| Reactant | Pyrrole-3-carboxylic acid | HCID 101030 | — |
| Reactant | 4-Methylbenzene-1-sulfonic acid--benzyl beta-alaninate (1/1) | HCID 13502100 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzyl 3-(3-pyrrolecarboxamido)propionate | HCID 10516322 | 88.6% |
Reaction Steps
Using 1.67 g (15 mmol) of 3-pyrrolecarboxylic acid, 6.33 g (18 mmol) of β-alanine benzyl ester p-toluenesulfonate, 2.94 g (18 mmol) of diethyl phosphorocyanidate, 3.64 g (36 mmol) of triethylamine and 50 ml of DMF, 3.62 g of the title compound were obtained in a similar manner as in Example 1 (yield: 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258805B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-09126364d0fd40148d09f4cc047dff78 |
| Source note | uspto-grants-2001_07 |