HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetate → 1-(4-Trifluoromethylanilino)-4-(4-pyridylmethyl)phthalazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetate | HCID 175 | — |
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Chloro-4-(4-pyridinylmethyl)phthalazine | HCID 1944609 | — |
| Product | 1-(4-Trifluoromethylanilino)-4-(4-pyridylmethyl)phthalazine | HCID 9929754 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 0.511 g (2 mmol) 1-chloro-4-(4-pyridylmethyl)phthalazine and 0.746 ml (6 mmol) 4-aminobenzotrifluoride is heated for 2.5 h at 100° C. The reaction mixture is then distributed between acetate and 20% aqueous potassium carbonate solution. The title compound is obtained after further processing as described in Example 7; m.p. 205-206° C.; ESI-MS: (M+H)+=381.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258812B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-08c745f12ed74b5a91acaa1efa7e39f9 |
| Source note | uspto-grants-2001_07 |