HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 7-Acetamino-1-anilino-4-(4-pyridylmethyl)phthalazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | 7-Acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine | HCID 22741951 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 7-Acetamino-1-anilino-4-(4-pyridylmethyl)phthalazine hydrochloride | HCID 22741994 | — |
Reaction Steps
By analogy with Example 25, 250 mg (0.80 mmol) 7-acetamino-1-chloro-4-(4-pyridylmethyl)-phthalazine is reacted in 3.2 ml 1-butanol with 0.22 ml (2.4 mmol) aniline to obtain title compound: m.p.: 162-166° C.; HPLC: tRet(Grad5-40)=9.75; FAB MS (M+H)+=370.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258812B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-0c1e751c2b4d44a0bc78d9050e68d861 |
| Source note | uspto-grants-2001_07 |