Succinic Acid → Vatalanib Succinate

Participants

Reaction Steps

A solution of 1.77 g (15 mmol) succinic acid in 35 ml ethanol is added to a hot solution of 5.0 g (14.4 mmol) 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine in 150 ml ethanol. As the mixture cools (scraping) to 0° C., a crystalline precipitate slowly forms, which is filtered off, washed with ethanol, and dried: Anal. calc. (C24H21N4ClO4)C 62.00%, H 4.55%, N 12.05%; found C 62.02%, H 4.75%, N 12.04%.

Provenance & Evidence