HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluidine → 3-(4-Methylanilino)-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | 3-Chloro-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine | HCID 10776025 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-(4-Methylanilino)-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine | HCID 22742019 | — |
Reaction Steps
The compound is prepared from 0.070 g 3-chloro-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine and 0.129 g para-methylaniline in the manner described in Example 82A. Title compound is obtained after FC in CH2Cl2/Methanol 19/1; m.p. 68-70° C. 1H-NMR (250 MHz,CDCl3): δ=8.45 (s, wide, 2H); 7.45 (d, 2H); 7.10 (“d”, wide, 4H); 6.10 (s, wide, 1H); 4.25 (s, 2H); 2.30 (s, 3H); 2.15 (s, 3H); 2.10 (s, 3H). ES-MS 305 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258812B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-8e45b58649d5439c9303c760aa90b0d3 |
| Source note | uspto-grants-2001_07 |