Diiodomethane → HCID 21185969, compound

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Reaction Steps

Diiodomethane (230 μl, 2.85 mmol) is added dropwise, at 60° C., to a mixture of methyl 2-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)vinyl]phenylcarboxylate (500 mg, 1.44 mmol) and a 1M solution of diethylzinc in heptane (2.9 ml, 2.9 mmol) in dichloromethane (10 ml). The heating is continued for 4 h. The solution is extracted with ethyl acetate. After separation of the phases by settling, the organic phase is washed with 1N HCl solution and then with water, dried over anhydrous magnesium sulfate and concentrated. The same process is repeated once.

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