Phenylboronic Acid → HCID 21186295, compound

Participants

Reaction Steps

1H NMR (d6-DMSO): 2.2 (s, 3H), 3.6 (s, 3H), 7.3-7.55 (m, 6H), 7.6 (dd, 1H), 8.4 (dd, 1H), 8.8 (dd, 1H), 10.5 (br s, 1H); mass spectrum (positive fast atom bombardment (+ve FAB), methanol/m-nitrobenzyl alcohol (NBA)): 357 (M+H)+; starting from N-(isobutoxycarbonyl)-N-(3-methoxy-5-methylpyrazin-2-yl)-2-phenylpyridine-3-sulphonamide; 1H NMR (d6-DMSO): 0.6 (d, 6H), 1.7 (m, 1H), 2.55 (s, 3H), 3.7 (d, 2H), 3.9 (s, 3H), 7.4-7.55 (m, 5H), 7.8 (dd, 1H), 8.9 (dd, 1H), 8.95 (dd, 1H); mass spectrum (+ve CI): 457 (M+H)+; itself obtained using an analogous procedure to that described in Example 1, part (iii) but using phenylboronic acid.

Provenance & Evidence