HCID 21186702, compound → HCID 21186786, compound

Participants

Reaction Steps

Methyl 8-hydroxy-2-methyl-5,6,7,8-tetrahydrocyclohexa[b]pyridine-3-carboxylate (3.95 g, 17.9 mmol) was dissolved in dichloromethane (80.0 ml), and the solution was mixed with activated manganese dioxide (23.29 g) and stirred at room temperature for 30 minutes. The reaction solution was diluted with ethyl acetate and then purified by a short column chromatography (ethyl acetate) and recrystallization (ethyl acetate-ether) to obtain the title compound (975.1 mg, 24.9%) as pale yellow needle crystals.

Provenance & Evidence