6-Bromo-4-(3-chlorophenyl)-2-methoxyquinoline → HCID 22465433, compound

HRID 1384348Notes

Reaction equation

HRID 1384348 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[CH:6]=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=1.[Cl:21][C:22]1[CH:26]=[CH:25][S:24][C:23]=1[C:27]([C:29]1[N:30]([CH3:34])[CH:31]=[N:32][CH:33]=1)=[O:28]>>[Cl:20][C:16]1[CH:15]=[C:14]([C:5]2[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([C:27]([C:23]4[S:24][CH:25]=[CH:26][C:22]=4[Cl:21])([C:29]4[N:30]([CH3:34])[CH:31]=[N:32][CH:33]=4)[OH:28])[CH:3]=3)[N:8]=[C:7]([O:12][CH3:13])[CH:6]=2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 120166726-Bromo-4-(3-chlorophenyl)-2-methoxyquinolineHCID 22465392(3-Chloro-thiophen-2-yl)-(3-methyl-3h-imidazol-4-yl)-methanone

Product 1

HCID 22465433HCID 22465433, compoundYield 51.2%

Procedure

Following the same procedure as described in example 1E, 6-bromo-4-(3-chloro-phenyl)-2-methoxy-quinoline (300 mg, 0.859 mmol) and (3-chloro-thiophen-2-yl)-(3-methyl-3H-imidazol-4-yl)-methanone (230 mg 1.032 mmol) generated the title compound of 21A as a yellow solid (218.5 mg, 51% yield).

Sources & evidence

ORD record
ord-d050e2b2bcc14e3cab77cf18fc5ff563
Source dataset
uspto-grants-2001_07
Patent number
US06258824B1

Reaction notes

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