HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-[(5-Chloro-thiophen-2-yl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-methoxy-phenyl)-1h-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (5-chloro-thiophen-2-yl)-[4-(3-methoxy-phenyl)-2-methoxy-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol | HCID 22465430 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-[(5-Chloro-thiophen-2-yl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-methoxy-phenyl)-1h-quinolin-2-one | HCID 22465436 | 100.1% |
Reaction Steps
Following the same procedure as described in example 1F (5-chloro-thiophen-2-yl)-[4-(3-methoxy-phenyl)-2-methoxy-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol (1.14 g, 2.34 mmol) was treated with HCl in aqueous THF to yield the title compound of 31B (1.12 g, 100% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258824B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-ac3b4ee7d3e6448fb3191bec68f33842 |
| Source note | uspto-grants-2001_07 |