1-Octanol → HCID 12642364, compound

Participants

Reaction Steps

To a suspension of 15.60 g sodium hydride (60%) in 200 ml of 1,2-dimethoxyethane, 50.79 g of 1-octanol was dropped in. The mixture was stirred for 45 minutes at room temperature. Then, 46.76 g of bromoacetonitrile was dropped in. The reaction mixture was refluxed for 2 hours, quenched with water, filtered, and diluted with brine. After extraction with ether, the organic layer was washed with brine and water, dried, filtered, and evaporated to dryness. The resulting dark oil was purified by distillation to yield a yellow oil.

Provenance & Evidence