HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-[4-(benzyloxy)phenyl]-2-ethoxyprop-2-enoate → 3-(4-Benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-[4-(benzyloxy)phenyl]-2-ethoxyprop-2-enoate | HCID 54423854 | — |
| Catalyst | Rhodium | HCID 23948 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-Benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester | HCID 11077968 | 10.2% |
Reaction Steps
3-(4-Benzyloxyphenyl)-2-ethoxyacrylic acid ethyl ester (0.5 g; 1.5 mmole) was hydrogenated at atmospheric pressure using rhodium on charcoal as catalyst (5%, 50 mg) in methanol (20 ml). The crude product was purified by chromatography using heptane:ethyl acetate (5:1) as eluant to give 50 mg (yield 10%) of 3-(4-benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258850B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-8b27509db9ac4397b1afc00043973fab |
| Source note | uspto-grants-2001_07 |