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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1384423Generated: October 25, 2026

3-(4-Benzyloxyphenyl)-(S)-2-ethoxypropanoic acid ethyl ester → Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

https://huagongshe.com/reaction/1384423

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Benzyloxyphenyl)-(S)-2-ethoxypropanoic acid ethyl esterHCID 11099514—
CatalystPalladiumHCID 23938—
SolventEthyl AcetateHCID 8857—
ProductEthyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 981614776%

Reaction Steps

3-(4-Benzyloxyphenyl)-(S)-2-ethoxypropanoic acid ethyl ester was hydrogenated at atmospheric pressure for 2 hours in ethyl acetate using Pd/C as catalyst. Purification by chromatography on silica gel using toluen:ethyl acetate as eluant gave 3.83 g (yield in 3 steps 76%) of (S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid ethyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06258850B1
Source datasetuspto-grants-2001_07
ORD IDord-229cf1459c1746f6878029c285912294
Source noteuspto-grants-2001_07