Acetaldehyde → 2-(N-Ethyl-p-toluidino)ethanol

HRID 1384426Notes

Reaction equation

[CH:1](=[O:3])[CH3:2].O[CH2:5][CH2:6][NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=1>>[CH2:6]([N:7]([CH2:2][CH2:1][OH:3])[C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=1)[CH3:5]

Participants

Reactant 2

HCID 177Acetaldehyde

HCID 2200082-p-Tolylamino-ethanol

Product 1

HCID 833952-(N-Ethyl-p-toluidino)ethanol

Procedure

N-ethyl-N-(2-hydroxyethyl)-p-toluidine (EHPT) was prepared substantially as described above in Example 1, except that acetaldehyde was added to ethylate N-(2-hydroxyethyl)-p-toluidine.

Sources & evidence

ORD record: ord-4d425734abc7422fb4fa1edd69e6d23d
Source dataset: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06258894B1

Reaction notes

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