HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 9820579, compound → Trimetrexate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 9820579 | HCID 9820579 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Trimetrexate | HCID 5583 | — |
Reaction Steps
The method of claim 21 wherein step (c) comprises heating the 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyphenylimino)methyl]quinazoline in a mixture of tetrahydrofuran and water in the presence of a reducing agent to produce a crude trimetrexate base, and converting the crude trimetrexate base to trimetrexate acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258952B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-8b0845638e394ca99b3c5c54728dce4f |
| Source note | uspto-grants-2001_07 |