2-(2-Hydroxyethyl)pyridine → 2-Piperidin-2-ylethanol

Temperature

10 °C

Low pressure hydrogenations were carried out by charging solvent, 2-pyridineethanol, and different quantities of various ruthenium supported catalysts into a pressure vessel capable of agitation, agitating the resulting mixture and pressurizing the vessel and its contents to 500 psi with hydrogen. Under constant hydrogen pressure and continued agitation, the reaction mixture was either heated to a constant reaction temperature or heated to an initial reaction temperature with incremental increases of 10° C. to a final reaction temperature. Reactions were allowed to continue until hydrogen uptake ceased. The pressure vessel and its contents were cooled, vented and the catalyst removed with vacuum filtration. Upon distillation of the filtrate, 2-piperidineethanol was obtained and analyzed on a gc column (6′ CW 20M 160° C.) to provide product yield and composition of the distillate. The results are provided in Table II.

1. temperaturethe reaction mixture was either heated to a constant reaction temperature
2. temperatureheated to an initial
3. customreaction temperature
4. customreaction temperature
5. temperatureThe pressure vessel and its contents were cooled
6. customthe catalyst removed with vacuum filtration
7. distillationUpon distillation of the filtrate

ORD record

ord-f0b410b554b4445e84bfcb1e19cfcf17

Source dataset

uspto-grants-2001_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06258955B1