[2-(2-Thienyl)ethylamino](2-chlorophenyl)acetonitrile → [2-(2-Thienyl)ethylamino](2-chlorophenyl)acetonitrile hydrochloride

Participants

Reaction Steps

276.7 g (1 mol) of [2-(2-thienyl)ethylamino](2-chlorphenyl)acetonitrile, prepared according to example 1 or 2, is dissolved in 600 ml of ethanol, to the solution 600 ml of 10% aqueous hydrochloric acid solution is added. Within a few minutes white crystals precipitate, then are collected, washed with 60 ml of 1:1 mixture of 10% hydrochloric acid and ethanol, then with acetone, and they are dried. Weight 305 g (97.4%), mp: 153-154° C. The product was identified by elemental analysis, IR spectrum and 1H-NMR investigation.

Provenance & Evidence