7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride → 4-(3-Acetoxy-4-methylanilino)-7-benzyloxy-6-methoxyquinazoline hydrochloride

Participants

Reaction Steps

A mixture of 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (2.18 g, 6.47 mmol), 3-acetoxy-4-methylaniline (1.32 g, 8 mmol) and isopropanol (50 ml) was stirred and heated at reflux for 1 hour. The mixture was cooled to ambient temperature. The precipitate was filtered off, washed with isopropanol and ether to give 4-(3-acetoxy-4-methylanilino)-7-benzyloxy-6-methoxyquinazoline hydrochloride (2.69 g, 89%).

Provenance & Evidence