Chloroform → 4-(3-Chloropropyl)pyridyl hydrochloride

Participants

Reaction Conditions

Reaction Steps

Thionyl chloride (1.6 ml) was added to a solution of 4-pyridine propanol (2 g, 14.5 mmol) in trichloromethane (20 ml) cooled at 0° C. After stirring for 1 hour at ambient temperature followed by 1 hour at 60° C., the solvent was evaporated and the residue was triturated with ether to give 4-(3-chloropropyl)pyridyl hydrochloride as a white solid. 1H NMR Spectrum: (DMSOd6) 2.15(m, 2H); 3.02(t, 2H); 3.69(t, 2H); 7.96(d, 2H); 8.84(d, 2H)

Provenance & Evidence