Sodium → HCID 21183870, compound

Participants

Reaction Steps

In a sulfonation flask, 1.66 g (0.02 mol) of sodium propylate and 1.5 g (0.00625 mol) of 2-methylsulfanyl-3-propyl-3H-thieno-[3.2-d]pyrimidin-4-one are stirred in 50 ml of absolute n-propanol for 3 hours under N2 at reflux temperature. The n-propanol is then removed in a water-jet vacuum and the residue is taken up in ethyl acetate/water and extracted three times with water. The organic phase is dried over sodium sulfate and the solvent is removed in the water-jet vacuum, giving the crude product which is then purified by column chromatography over silica gel (eluant: ethyl acetate/hexane 1:3). 1.22 g of 2-propoxy-3-propyl-3H-thieno[3.2-d]pyrimidin-4-one are obtained in the form of a beige powder having a melting point of 42-45° C.

Provenance & Evidence