HuagongsheHuagongshe Chemistry Print Report · For research reference only
CBz-D-phenylglycine 4-(1-methylpiperidin-4-yl)piperidinamide → D-Phenylglycine 4-(1-methylpiperidin-4-yl)piperidinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | CBz-D-phenylglycine 4-(1-methylpiperidin-4-yl)piperidinamide | HCID 131722772 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | D-Phenylglycine 4-(1-methylpiperidin-4-yl)piperidinamide | HCID 131722773 | 76% |
Reaction Steps
A vigorously stirred solution of CBz-D-phenylglycine-4-(1-methylpiperidin-4-yl)piperidinamide (1.1 g, 2.45 mmol) in methanol (120 ml), containing Palladium on carbon (200 mg ) was treated with hydrogen gas (balloon) at atmospheric pressure overnight. The reaction mixture was filtered through celite and concentrated to yield the title compound as a colourless oil (585 mg, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06262069B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-2e601390331741ff9e9e8717f24d47ad |
| Source note | uspto-grants-2001_07 |