Phosphorus tribromide → 7-(Bromomethyl)-1-isoquinolinamine

Participants

Reaction Steps

1-Amino-7-hydroxymethylisoquinoline (0.2 g) was dissolved in dry THF (10 ml.) and phosphorous tribromide (0.03 ml.) added in one portion. A white precipitate was seen to form and the suspension was stirred for 1 hr. at room temperature. The mixture was evaporated to dryness and triturated with diethylether to give the product.

Provenance & Evidence