HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(thiazole-4-carbonyl)-piperazin-1-yl]quinazoline Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline | HCID 616267 | — |
| Reactant | 1,3-Thiazole-4-carbonyl chloride | HCID 15572100 | — |
| Product | 4-Amino-6,7-dimethoxy-2-[4-(thiazole-4-carbonyl)-piperazin-1-yl]quinazoline Hydrochloride | HCID 21183937 | — |
Reaction Steps
The title compound was prepared from thiazole-4-carbonyl chloride (1.02 g.) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (2.00 g.) following previously described procedures. The product had a m.p. of 274°-277° C. with decomposition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06262059B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-8e938068c6f249b0876d7191ca4d4a7d |
| Source note | uspto-grants-2001_07 |