HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopentanecarbonylpiperazine → 4-Amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl)-6,7-dimethoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopentanecarbonylpiperazine | HCID 15512779 | — |
| Reactant | 6,7-Dimethoxy-2-(methylthio)quinazolin-4-amine | HCID 53862523 | — |
| Solvent | Isoamyl Alcohol | HCID 31260 | — |
| Product | 4-Amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl)-6,7-dimethoxyquinazoline | HCID 21183887 | — |
Reaction Steps
A mixture of 4-amino-2-methylmercapto-6,7-dimethoxyquinazoline (0.1 mole) and from 0.1 to 0.15 mole of N-(cyclopentylcarbonyl)piperazine in 150 ml. of isoamyl alcohol is refluxed for a period of 8 to 24 hours. The solvent is evaporated and residual material, treated according to procedure of Example 127(a), provides 4-amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06262059B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-4217c30e602b4626a1be9b909a78c899 |
| Source note | uspto-grants-2001_07 |