2-Chloro-6,7-dimethoxy-4-quinazolinamine → 6,7-Dimethoxyquinazoline

HRID 1384957Notes

Reaction equation

HRID 1384957 reaction equation
C1(C(N2CCNCC2)=O)CC=CC1.Cl[C:15]1[N:24]=[C:23](N)[C:22]2[C:17](=[CH:18][C:19]([O:28][CH3:29])=[C:20]([O:26][CH3:27])[CH:21]=2)[N:16]=1>>[CH3:27][O:26][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][C:19]=1[O:28][CH3:29])[N:16]=[CH:15][N:24]=[CH:23]2

Participants

3

Reactant 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 21184018HCID 21184018, compound

Product 1

HCID 30316616,7-Dimethoxyquinazoline

Procedure

N-(3-cyclopentenylcarbonyl)piperazine (2.7 g., 0.015 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (3.6 g., 0.015 mole) are reacted according to the procedure of Example 127(a). The crude product crystallized from methanol affords analytically pure 4-amino-2-4-(3-cyclopentenylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 215.5°-217.5° C. (corr.).

Workup

  1. customThe crude product crystallized from methanol

Sources & evidence

ORD record
ord-11088b9a8e84471facd5a19d6362d90d
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Reaction notes

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