2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 21184007, compound

HRID 1384958Notes

Reaction equation

HRID 1384958 reaction equation
[CH:1]1([C:5]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[O:6])[CH2:4][CH2:3][CH2:2]1.[Cl:13][C:14]1[N:23]=[C:22]([NH2:24])[C:21]2[C:16](=[CH:17][C:18]([O:27][CH3:28])=[C:19]([O:25][CH3:26])[CH:20]=2)[N:15]=1>>[OH2:6].[ClH:13].[NH2:24][C:22]1[C:21]2[C:16](=[CH:17][C:18]([O:27][CH3:28])=[C:19]([O:25][CH3:26])[CH:20]=2)[N:15]=[C:14]([N:10]2[CH2:9][CH2:8][N:7]([C:5]([CH:1]3[CH2:2][CH2:3][CH2:4]3)=[O:6])[CH2:12][CH2:11]2)[N:23]=1

Participants

3

Reactant 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 16777642Cyclobutyl(piperazin-1-yl)methanone

Product 1

HCID 21184007HCID 21184007, compound

Procedure

N-(Cyclobutylcarbonyl)piperazine (0.02 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (0.02 mole) are reacted according to the procedure of Example 127(a). When reaction is complete, the solvent is removed and the residue crystallized from methanolisopropanol to provide analytically pure 4-amino-2-[4-(cyclobutylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline hydrochloride hydrate, m.p. 267°-268° C. (dec.)(corr.).

Workup

  1. customWhen reaction
  2. customthe solvent is removed
  3. customthe residue crystallized from methanolisopropanol

Sources & evidence

ORD record
ord-b73b6e0958a247e9a1960fa05baee53f
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Reaction notes

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