HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 18545799, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 6-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 10059854 | — |
| Reactant | 3,6,7,8-Tetrahydrocyclopent[e]indole-8-carboxylic acid | HCID 18545892 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18545799 | HCID 18545799 | 38.5% |
Reaction Steps
A solution of 14a (1.4 g), 6-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1-H-indole (1.6 g), dicyclohexylcarbodiimid (1.9 g), and 4-dimethylaminopyridine (0.1 g) in THF (100 ml) was stirred for 24 hours at room temperature. The mixture was filtered and evaporated in vacuo. The residue was purified on silica gel eluted with ethyl acetate-heptane (3:2) giving 1.1 g of the title product as an amorpheous powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06262087B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-c357f3702d8f42afacc43c7139e257ac |
| Source note | uspto-grants-2001_07 |