6-Chloro-3-piperidin-4-YL-1H-indole → 3-[1-[2-(1-Acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]piperidin-4-yl]-6-chloro-1h-indole

Participants

Role	Name	HCID	Charge
Reactant	6-Chloro-3-piperidin-4-YL-1H-indole	HCID 12072040	—
Reactant	1-Acetyl-2,3-dihydro-3-[2-(methanesulphonyl)ethyl]-1H-indole	HCID 18545886	—
Product	3-[1-[2-(1-Acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]piperidin-4-yl]-6-chloro-1h-indole	HCID 18545967	—

Reaction Steps

From 19a and 6-chloro-3-(piperidin-4-yl)-1H-indole (EP Patent publication No 465398-A1). Mp 188-90° C. 1H NMR (DMSO-d6) d 1.70-1.90 (m, 3H), 1.95-2.20 (m, 5H), 2.25 (s, 3H), 2.40-2.55 (m, 2H), 2.80 (tt, 1H), 3.00-3.10 (m, 2H), 3.40-3.55 (m, 1H), 3.75 (dd, 1H), 4.20 (t, 1H), 6.95 (d, 1H), 7.05 (ddd, 1H), 7.25 (dt, 1H), 7.35 (d, 1H), 7.55 (d, 1H), 8.00 (s, 1H), 8.25 (d, 1H). MS m/z (%): 422 (MH+, 100%), 249 (15%), 146 (19%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06262087B1
Source dataset	uspto-grants-2001_07
ORD ID	ord-edf8594d853d43139afe1170bcd6a810
Source note	uspto-grants-2001_07