4-Pyridineethanamine → HCID 15547423, compound

HRID 1385101Notes

Reaction equation

HRID 1385101 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:15](Cl)=[O:16])[CH:13]=3)[C:8]([CH2:18][CH3:19])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=1>>[N:26]1[CH:27]=[CH:28][C:23]([CH2:22][CH2:21][NH:20][C:15]([C:12]2[CH:13]=[C:14]3[C:9]([C:8]([CH2:18][CH3:19])=[N:7][N:6]3[CH:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[CH:10][CH:11]=2)=[O:16])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 832754-PyridineethanamineHCID 15545850HCID 15545850, compound

Product 1

HCID 15547423HCID 15547423, compoundYield 35%

Procedure

This compound was prepared according to the method of Example 15, using 78 mg (0.282 mmol, 1.0 equiv) 1-cyclopentyl-3-ethyl-1H-indazole-6-carbonyl chloride and 36 μL (0.295 mmol, 1.05 equiv) 4-(2-aminoethyl)pyridine as starting materials, to give 35 mg (35%) of white crystals: mp 123-126° C.; Anal. calcd for C22H26N4O.¼H2O: C, 72.01; H, 7.28; N, 15.27. Found: C, 71.77; H, 7.45; N, 15.23.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-2fb38649840e42dd963dade0d38e7283
Source dataset
uspto-grants-2001_07
Patent number
US06262040B1

Reaction notes

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