beta-Alanine, ethyl ester, hydrochloride → HCID 53979019, compound

HRID 1385114Notes

Reaction equation

HRID 1385114 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:15]([OH:17])=O)[CH:13]=3)[C:8]([CH2:18][CH3:19])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH2:21]([O:23][C:24](=[O:28])[CH2:25][CH2:26][NH2:27])[CH3:22]>>[CH2:21]([O:23][C:24](=[O:28])[CH2:25][CH2:26][NH:27][C:15]([C:12]1[CH:13]=[C:14]2[C:9]([C:8]([CH2:18][CH3:19])=[N:7][N:6]2[CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[CH:10][CH:11]=1)=[O:17])[CH3:22]

Participants

3

Reactant 2

HCID 458475beta-Alanine, ethyl ester, hydrochlorideHCID 15545851HCID 15545851, compound

Product 1

HCID 53979019HCID 53979019, compoundYield 90.5%

Procedure

This compound was prepared according to the method of Example 35, using 297 mg (1.15 mmol, 1.0 equiv) 1-cyclopentyl-3-ethyl-1H-indazole-6-carboxylic acid and 177 mg (1.15 mmol, 1.0 equiv) beta-alanine ethyl ester hydrochloride as starting materials to give 372 mg (90%) of white crystals: mp 74-76° C.; Anal. calcd for C20H27N3O3: C, 67.21; H, 7.61; N, 11.76. Found: C, 67.40; H, 7.56; N, 11.99.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-13364aeb6c07414189c51b28971ed48c
Source dataset
uspto-grants-2001_07
Patent number
US06262040B1

Reaction notes

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