Ethyl N-methylaminoacetate hydrochloride → HCID 70247003, compound

HRID 1385118Notes

Reaction equation

HRID 1385118 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:15]([OH:17])=O)[CH:13]=3)[C:8]([CH2:18][CH3:19])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH2:21]([O:23][C:24](=[O:28])[CH2:25][NH:26][CH3:27])[CH3:22]>>[CH2:21]([O:23][C:24](=[O:28])[CH2:25][N:26]([C:15]([C:12]1[CH:13]=[C:14]2[C:9]([C:8]([CH2:18][CH3:19])=[N:7][N:6]2[CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[CH:10][CH:11]=1)=[O:17])[CH3:27])[CH3:22]

Participants

3

Reactant 2

HCID 171173Ethyl N-methylaminoacetate hydrochlorideHCID 15545851HCID 15545851, compound

Product 1

HCID 70247003HCID 70247003, compoundYield 56%

Procedure

This compound was prepared according to the method of Example 35, using 284 mg (1.10 mmol, 1.0 equiv) 1-cyclopentyl-3-ethyl-1H-indazole-6-carboxylic acid and 169 mg (1.10 mmol, 1.0 equiv) sarcosine ethyl ester hydrochloride as starting materials, to give 220 mg (56%) of a clear oil: Anal. calcd for C20H27N3O3: C, 67.21; H, 7.61; N, 11.76. Found: C, 66.93; H, 7.73; N, 11.77.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-bd13ab8959784d098593956e7e5ab09a
Source dataset
uspto-grants-2001_07
Patent number
US06262040B1

Reaction notes

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