1-chloro-5-isocyanato-2,4-dimethoxybenzene → HCID 15907987, compound

HRID 1385275Notes

Reaction equation

HRID 1385275 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:17])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])=[CH:4][CH:3]=1.[Cl:18][C:19]1[C:20]([O:30][CH3:31])=[CH:21][C:22]([O:28][CH3:29])=[C:23]([N:25]=[C:26]=[O:27])[CH:24]=1>C(#N)C>[Cl:18][C:19]1[C:20]([O:30][CH3:31])=[CH:21][C:22]([O:28][CH3:29])=[C:23]([NH:25][C:26](=[O:27])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:17])[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[F:16])=[CH:6][CH:7]=2)[CH:24]=1

Participants

4

Reactant 2

HCID 43898041-chloro-5-isocyanato-2,4-dimethoxybenzeneHCID 15922851HCID 15922851, compound

Product 1

HCID 15907987HCID 15907987, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension of N-(4-amino-phenyl)-2-fluoro-benzamide (0.43 g) in acetonitrile (4 mL) is treated with 5-chloro-2,4-dimethoxyphenylisocyanate (0.40 g). The mixture becomes a solution and is allowed to stand for 12 hours. A white solid forms and is collected by filtration (0.79 g). [M+H] 444.

Workup

  1. filtrationA white solid forms and is collected by filtration (0.79 g)

Sources & evidence

ORD record
ord-2c8bfd88327641c4aba3116feeff45ae
Source dataset
uspto-grants-2001_07
Patent number
US06262090B1

Reaction notes

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