1-bromo-3-methylsulfanyl-6,7-dihydro-5H-2-benzothiophen-4-one → 3-Methylthio-1-(oxazol-2-yl)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one

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Reaction Steps

In a similar way to that in Example 35, using 1-bromo-3-methylthio-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one and 2-(tri-n-butylstannyl)oxazole, the title compound was isolated as a pale yellow solid (35 mg, 37%). mp 157-159° C. Found: C, 54.0; H, 3.7; N, 5.6%. C12H11NO2S2 requires: C, 54.32; H, 4.18; N, 5.28%. 1HNMR (250 MHz, CDCl3) δ 2.05-2.16 (2H, m), 2.56-2.61 (2H, m), 2.63 (3H, s), 3.20-3.25 (2H, m), 7.20 (1H, s), 7.66 (1H, s). MS (ES+) 266 (M+1).

Provenance & Evidence