Thiophosgene → N-(2-tert-butyldimethysilyloxy-4-nitrophenyl)-N'-phenyl-thiourea

HRID 1385338Notes

Reaction equation

HRID 1385338 reaction equation
[Si:1]([O:8][C:9]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:10]=1[NH2:11])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[C:24](Cl)(Cl)=[S:25]>>[Si:1]([O:8][C:9]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:10]=1[NH:11][C:24]([NH:11][C:10]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:9]=1)=[S:25])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 10040ThiophosgeneHCID 516892Sodium BicarbonateHCID 154857102-[(Tert-butyldimethylsilyl)oxy]-4-nitroaniline

Product 1

HCID 15524278N-(2-tert-butyldimethysilyloxy-4-nitrophenyl)-N'-phenyl-thioureaYield 98%

Conditions

Temperature
23 °C

Procedure

N-(2-tert-Butyldimethysilyloxy-4-nitrophenyl)-N′-phenyl-thiourea was prepared by treating a biphasic solution of 2-tert-butyldimethysilyloxy-4-nitroaniline (80 mg, 0.308 mmol) and NaHCO3 in CHCH3:H2O (2.5:1, 7 mL) with thiophosgene at 0° C. The solution was allowed to warm to 23° C. and the reaction was continued overnight. The CHCH3 layer was separated and dried over sodium sulfate. The solution was concentrated in vacuo and the residue was dissolved in toluene and treated with aniline (100 uL) at 23° C. for 12 h. The reaction mixture was concentrated and the residue was purified by flash chromatography (10% EtOAc/hexanes) to afford the titled compound as a yellow solid (120.8 mg, 98%) mp: 144-145° C.; 1H NMR (CD3OD/CDCl3): d 8.65 (d, 1H, J=10.0 Hz), 7.58 (d, 1H, J=10.0 Hz), 7.47 (d, 1H, J=1.25 Hz), 7.26 (m, 4H), 7.10 (m, 1H).

Workup

  1. customN-(2-tert-Butyldimethysilyloxy-4-nitrophenyl)-N′-phenyl-thiourea was prepared
  2. customThe CHCH3 layer was separated
  3. dry with materialdried over sodium sulfate
  4. concentrationThe solution was concentrated in vacuo
  5. dissolutionthe residue was dissolved in toluene
  6. additiontreated with aniline (100 uL) at 23° C. for 12 h
  7. concentrationThe reaction mixture was concentrated
  8. customthe residue was purified by flash chromatography (10% EtOAc/hexanes)

Sources & evidence

ORD record
ord-577b0cf550d84b439ff39fbd3a577f21
Source dataset
uspto-grants-2001_07
Patent number
US06262113B1

Reaction notes

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