2-Bromophenyl isocyanate → (2-Bromophenyl)urea

HRID 1385372Notes

Reaction equation

HRID 1385372 reaction equation
OC1C=C(C=CC=1[NH2:11])C(O)=O.[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]=[C:20]=[O:21]>>[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH:19][C:20](=[O:21])[NH2:11]

Participants

3

Reactant 2

HCID 1370972-Bromophenyl isocyanateHCID 1375664-Amino-3-hydroxybenzoic acid

Product 1

HCID 139386(2-Bromophenyl)urea

Procedure

The urea was prepared from 3-hydroxy 4-amino benzoic acid (3.69 g, 24 mmol) and 2-bromo phenyl isocyanate (24 mmol) by general Method B. It was purified by dilution of the DMF solution with methylene chloride and precipitation with hexane (4.0 g, 48%). EI-MS m/z 351 (M+H)+

Workup

  1. customIt was purified by dilution of the DMF solution with methylene chloride and precipitation with hexane (4.0 g, 48%)

Sources & evidence

ORD record
ord-1ff087aea22545b7927be2dd5f41094e
Source dataset
uspto-grants-2001_07
Patent number
US06262113B1

Reaction notes

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