1-(4-Fluorophenyl)cyclopentanecarboxylic acid → 1-(4-fluoro-phenyl)-cyclopentanecarboxylic acid {(3RS,4SR)-4-(3,4-dichloro-phenyl)-1-[1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-methyl-amide

HRID 138545Notes

Reaction equation

HRID 138545 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][N:11]([C:16](=[O:17])[CH:18]3[CH2:19][CH2:20][N:21]([C:24](=[O:25])[C:26]4([CH3:29])[CH2:27][CH2:28]4)[CH2:22][CH2:23]3)[CH2:12][CH:13]2[NH:14][CH3:15])[cH:5][cH:6][c:7]1[Cl:8].[F:30][c:31]1[cH:32][cH:33][c:34]([C:37]2([C:42](=[O:43])[OH:44])[CH2:38][CH2:39][CH2:40][CH2:41]2)[cH:35][cH:36]1>>[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][N:11]([C:16](=[O:17])[CH:18]3[CH2:19][CH2:20][N:21]([C:24](=[O:25])[C:26]4([CH3:29])[CH2:27][CH2:28]4)[CH2:22][CH2:23]3)[CH2:12][CH:13]2[N:14]([CH3:15])[C:42]([C:37]2([c:34]3[cH:33][cH:32][c:31]([F:30])[cH:36][cH:35]3)[CH2:38][CH2:39][CH2:40][CH2:41]2)=[O:44])[cH:5][cH:6][c:7]1[Cl:8]

Participants

3

Reactant 2

HCID 7361331-(4-Fluorophenyl)cyclopentanecarboxylic acidHCID 67025815[(3SR,4RS)-3-(3,4-Dichloro-phenyl)-4-methylamino-pyrrolidin-1-yl]-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yl]-methanone

Product 1

HCID 670256751-(4-fluoro-phenyl)-cyclopentanecarboxylic acid {(3RS,4SR)-4-(3,4-dichloro-phenyl)-1-[1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-methyl-amide

Sources & evidence

ORD record
ord-5155488ec8e44f39a2d3d8ece2c087c5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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