Hydrogen Peroxide → HCID 11043886, compound

Participants

Reaction Conditions

Reaction Steps

8.4 g (0.124 mol) of 50% strength hydrogen peroxide were added with stirring at 15-20° C. in the course of 15 minutes to a mixture of 31 g (0.1213 mol) of 3-chloro-2-n-propylthio-5-trifluoromethylpyridine in 150 ml of acetic acid, during which process the temperature rose to 27° C. in the course of 6 hours. After the reaction mixture had been stirred for 14 hours at 25° C., it was poured into ice-water and extracted 3 times with methylene chloride. The organic phase was washed with water and saturated sodium hydrogen carbonate solution, dried and concentrated in vacuo, yielding 32 g (97.2% of theory) of the title compound of m.p. 51-53° C.

Provenance & Evidence