1H-Imidazole-1-propanamine → HCID 136364219, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the nucleoside 102 (10.31 g, 36 mmol) and 1-(3-amino-propyl) imidazol (9 g, 72 mmole) in 2-methoxyethanol (60 ml) was heated in a steel bomb at 120° C. (oil bath) for 24 hrs. The bomb was cooled to 0° C., opened carefully and the precipitated solid was filtered. The solid was washed with methanol (50 ml) and acetone (50 ml), and dried over sodium hydroxide to give 9 g (67%) of pure 103. A small amount was recrystallized from DMF for analytical purposes. mp 245-47°.

Provenance & Evidence