1,1'-(Chlorophenylmethylene)bis(4-methoxybenzene) → HCID 136475464, compound

HRID 1385542Notes

Reaction equation

HRID 1385542 reaction equation
[C:1]([N:6]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:7]1[NH:8][C:9](=[O:24])[C:10]2[N:11]=[CH:12][N:13]([C:22]=2[N:23]=1)[C@@H:14]1[O:21][C@H:18]([CH2:19][OH:20])[C@@H:16]([OH:17])[CH2:15]1)(=[O:5])[CH:2]([CH3:4])[CH3:3].[C:34](Cl)([C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)([C:43]1[CH:50]=[CH:49][C:46]([O:47][CH3:48])=[CH:45][CH:44]=1)[C:35]1[CH:42]=[CH:41][C:38]([O:39][CH3:40])=[CH:37][CH:36]=1>N1C=CC=CC=1>[CH3:48][O:47][C:46]1[CH:45]=[CH:44][C:43]([C:34]([O:20][CH2:19][C@H:18]2[O:21][C@@H:14]([N:13]3[C:22]4[N:23]=[C:7]([N:6]([C:1](=[O:5])[CH:2]([CH3:3])[CH3:4])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[NH:8][C:9](=[O:24])[C:10]=4[N:11]=[CH:12]3)[CH2:15][C@@H:16]2[OH:17])([C:51]2[CH:52]=[CH:53][CH:54]=[CH:55][CH:56]=2)[C:35]2[CH:42]=[CH:41][C:38]([O:39][CH3:40])=[CH:37][CH:36]=2)=[CH:50][CH:49]=1

Participants

4

Reactant 2

HCID 968311,1'-(Chlorophenylmethylene)bis(4-methoxybenzene)HCID 137182977HCID 137182977, compound2×

Product 1

HCID 136475464HCID 136475464, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Compound 118 was prepared from compound 117 by following the procedure of example 107 utilizing compound 117 (2.2 g, 4.75 mmole), DMTCl (1.69 g, 5 mmole), dry TEA (1.01 g, 10 mmole) and dry pyridine (70 ml). The crude compound was purified using flash chromatography and methylene chloride/methanol/TEA as the eluent. 2 g (55%) of pure product was obtained as a foam.

Workup

  1. customThe crude compound was purified

Sources & evidence

ORD record
ord-478e059ba0724f2287a841343d61df1b
Source dataset
uspto-grants-2001_07
Patent number
US06262241B1

Reaction notes

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