1,1'-(Chlorophenylmethylene)bis(4-methoxybenzene) → HCID 88058737, compound

HRID 1385543Notes

Reaction equation

HRID 1385543 reaction equation
[C:1]([NH:9][C:10]1[C:11]2[N:12]=[CH:13][N:14]([C:23]=2[N:24]=[C:25]([Cl:27])[N:26]=1)[C@@H:15]1[O:22][C@H:19]([CH2:20][OH:21])[C@@H:17]([OH:18])[CH2:16]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:28](Cl)([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)([C:37]1[CH:44]=[CH:43][C:40]([O:41][CH3:42])=[CH:39][CH:38]=1)[C:29]1[CH:36]=[CH:35][C:32]([O:33][CH3:34])=[CH:31][CH:30]=1>N1C=CC=CC=1>[CH3:42][O:41][C:40]1[CH:39]=[CH:38][C:37]([C:28]([O:21][CH2:20][C@H:19]2[O:22][C@@H:15]([N:14]3[C:23]4[N:24]=[C:25]([Cl:27])[N:26]=[C:10]([NH:9][C:1](=[O:8])[C:2]5[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=5)[C:11]=4[N:12]=[CH:13]3)[CH2:16][C@@H:17]2[OH:18])([C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=2)[C:29]2[CH:36]=[CH:35][C:32]([O:33][CH3:34])=[CH:31][CH:30]=2)=[CH:44][CH:43]=1

Participants

4

Reactant 2

HCID 968311,1'-(Chlorophenylmethylene)bis(4-methoxybenzene)HCID 54528182HCID 54528182, compound2×

Product 1

HCID 88058737HCID 88058737, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Compound 123 was prepared from compound 122 as per the procedure of example 107 using compound 122 (2.5 g, 6.43 mmol), DMTCl (2.37 g, 7 mmol), dry TEA (0.71 g, 7 mmol) and dry pyridine (100 ml). The crude product was purified by flash chromatography using methylene chloride→ethyl acetate containing 18 TEA as the eluent to give 3 g (68%) of pure 123 as a foam.

Workup

  1. customThe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-d0e36877a4c946e2853733e98208f78d
Source dataset
uspto-grants-2001_07
Patent number
US06262241B1

Reaction notes

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